Strattera (Atomoxetine) – Patient-Friendly Information (UK)

Strattera is a prescription medicine used to treat attention deficit hyperactivity disorder (ADHD). This page explains how it works, how it is taken, and important safety information in a clear, patient-friendly way for people in the United Kingdom.

Always follow the instructions given by your healthcare professional and read the patient information leaflet provided with your medicine.

Quick overview

Basic product information

• Brand name: Strattera
• Generic name: atomoxetine
• Medicine type: Non-stimulant ADHD medication
• Common strengths: Capsules are available in multiple dose strengths (your pharmacy will supply the strength prescribed).
• How it is taken: By mouth, usually once or twice daily depending on the dose.

In the UK, atomoxetine is regulated as a prescription-only medicine. It is supplied under national medicines regulations and is dispensed in accordance with UK pharmacy requirements.

How Strattera works (mechanism of action)

Strattera contains atomoxetine, which works differently from stimulant ADHD medicines.

Mechanism of action: Atomoxetine is a selective norepinephrine reuptake inhibitor. It increases levels of norepinephrine in the brain by blocking its reuptake. This can help improve attention and reduce core ADHD symptoms such as impulsivity and hyperactivity.

Why this matters: Because it is not a stimulant, Strattera typically does not produce the same “immediate” effect as some fast-acting ADHD drugs. Many people notice gradual improvement over time.

Pharmacokinetics (what the body does to the medicine)

Absorption: After taking by mouth, atomoxetine is absorbed from the gastrointestinal tract. Food can affect the speed of absorption but generally not the overall amount absorbed.

Distribution: Atomoxetine distributes through the body and crosses into the brain.

Metabolism: The liver metabolises atomoxetine mainly through the enzyme CYP2D6. Some people are “slow metabolisers,” which can lead to higher medicine levels in the body.

Elimination: Atomoxetine is cleared from the body primarily through metabolism and subsequent elimination via urine and faeces.

Half-life (general concept): The medicine’s effects last beyond a single dose, which is why dosing may be once or twice daily depending on your regimen.

What Strattera is used for (indications)

In the UK, Strattera is used to treat ADHD in:

• Children and adolescents (age ranges depend on the UK marketing authorisation and your healthcare provider’s assessment).
• Adults with ADHD.

It may be chosen when:

• stimulant medicines are unsuitable or not well tolerated, or
• symptom control needs to be managed over time in a different way to stimulants, or
• there are concerns about stimulant side effects or misuse potential.

Timing: when to take it and how long it takes to work

Start-up and adjustment: Strattera dosing is usually started at a lower level and gradually increased to help reduce side effects and improve tolerability.

How quickly it may work:

• Some people notice changes within 1–4 weeks.
• For others, it can take several weeks to achieve full benefit.
• It is common for improvement to continue after the initial dose adjustment period.

Take it at the same time(s) each day. If you miss a dose, follow the guidance provided by your healthcare professional or the leaflet. (In general, do not double up to make up for a missed dose.)

How to take Strattera (practical dosing guidance)

Because every patient is different, your prescriber will determine the appropriate dose and schedule. Below is general information to help you understand what is commonly done.

Typical dosing approach

• Children & adolescents: Dose is weight- or age-dependent, with gradual titration.
• Adults: Often started at a lower dose and increased based on response and tolerability.

Once-daily vs twice-daily

• Once daily may be suitable for many people.
• Twice daily dosing may be used to better control side effects or to spread the effect.

Swallowing and missed doses

• Swallow capsules whole with water.
• Do not open or crush capsules unless advised.
• If you miss a dose, consult the leaflet instructions. If you are unsure, speak to your pharmacist for guidance.

Monitoring: Your clinician may monitor ADHD symptoms, blood pressure, heart rate, weight, and general wellbeing during treatment.

Food interactions and taking with meals

Food may influence how quickly atomoxetine is absorbed.

• In many cases, Strattera can be taken with or without food.
• If you experience nausea or stomach discomfort, taking it with food may help.
• Try to keep your routine consistent (for example, always with breakfast or always on an empty stomach), unless your clinician advises otherwise.

Grapefruit and other specific foods: There is no universal instruction about avoiding particular foods, but if you have complex medical issues or take multiple medicines, it is safer to check individual interactions with a pharmacist.

Alcohol and medicine interactions

Alcohol

Atomoxetine can affect alertness and cause side effects such as dizziness or tiredness in some people. Alcohol may increase these effects.

• For safety, it’s generally best to limit alcohol and avoid binge drinking.
• If you notice increased drowsiness, dizziness, or worsening mood symptoms after drinking, avoid alcohol and seek advice from a healthcare professional.

Medicine interactions

Atomoxetine is metabolised mainly by CYP2D6. Medicines that influence this enzyme can raise or lower atomoxetine levels.

Examples of interaction types to be aware of (not an exhaustive list):

• Medicines that inhibit CYP2D6 may increase atomoxetine exposure, potentially raising side effects.
• Medicines that affect blood pressure or heart rate can increase the need for monitoring.
• Antidepressants (some types) may interact through CYP2D6 or additive effects on mood/sleep.
• Other ADHD medicines may be co-prescribed in specific situations—always confirm whether combining medicines is intended and safe.

Always tell your pharmacist/doctor about all medicines and supplements you take, including:

• prescription medicines
• over-the-counter products
• herbal remedies (for example, St John’s wort)
• pain medicines and cough/cold medicines

Do not start or stop interacting medicines without professional advice.

Safety profile: common side effects and when to seek help

Like all medicines, Strattera can cause side effects. Many people experience mild, temporary effects, especially early in treatment or after dose changes. However, some effects may require prompt medical attention.

Common side effects

• Nausea
• Decreased appetite
• Dry mouth
• Constipation
• Dizziness
• Sleep changes (including insomnia or drowsiness)
• Fatigue
• Headache
• Increased heart rate or blood pressure changes (some people)

Less common but important risks

• Allergic reactions (e.g., rash, swelling, trouble breathing)
• Mood changes or worsening anxiety in some individuals
• Urination problems or sexual side effects (can occur)
• Signs of liver problems such as yellowing of the skin/eyes, dark urine, or severe fatigue

Seek urgent medical advice if

• you develop swelling of the face/lips, difficulty breathing, or severe rash
• you experience thoughts of self-harm or severe mood worsening
• you notice yellowing of the skin/eyes (jaundice) or persistent upper abdominal pain
• you have severe dizziness, fainting, chest pain, or a markedly fast heartbeat

If you are concerned about any side effect, contact a healthcare professional promptly. In an emergency, contact emergency services.

Special populations and precautions

Strattera may require extra caution in some situations. Discuss these with your prescriber:

• Heart conditions or history of cardiovascular problems
• High blood pressure or irregular heart rhythms
• Liver impairment (dose adjustments may be necessary)
• Slow CYP2D6 metabolisers (atomoxetine levels can be higher)
• Existing mental health conditions (monitor mood and anxiety)
• Children and teenagers: appetite and growth should be monitored over time
• Pregnancy and breastfeeding: discuss risks and benefits with your clinician

Dosing overview (general information)

Dosing is individual. The information below is a high-level guide to how dosing is typically approached, not a substitute for personalised instructions.

Initial titration

• Strattera is commonly started at a low dose.
• Your clinician may increase the dose gradually over time.
• Titration aims to balance symptom benefit and side effect risk.

Maintenance

• After achieving an effective dose, dosing usually continues long-term if it remains beneficial and safe.
• Some people may require periodic review of dose due to symptom changes, age, or side effects.

Stopping

Do not stop atomoxetine suddenly unless advised by a healthcare professional. Your clinician may want to plan changes to ensure symptoms remain controlled and side effects are managed.

Practical use tips for day-to-day success

• Use a routine: Take Strattera at the same time(s) each day (set a reminder if helpful).
• Track symptoms: Note improvements and any side effects, especially during the first weeks or after dose changes.
• Manage appetite: If appetite decreases, consider smaller meals, nutrient-dense foods, and avoid skipping meals. Your clinician may monitor weight in children and adolescents.
• Support sleep: If you get insomnia, take your dose earlier in the day (discuss timing with your pharmacist/doctor before changing your schedule).
• Hydration helps: Dry mouth can improve with frequent sips of water and good oral hygiene.
• Be cautious with dizziness: If you feel light-headed, avoid driving or operating machinery until you know how you react.
• Keep appointments: Regular follow-ups help optimise dose and monitor safety.

Alternative options for ADHD in the UK

ADHD treatment is individual. Alternative options may include:

Non-medicine approaches

• Behavioural therapy (for children and adults)
• Parent training programmes and structured behavioural strategies
• Educational support and workplace adjustments
• Psychological interventions (e.g., CBT approaches tailored for ADHD)

Other medicines

• Stimulant ADHD medicines (for example, methylphenidate-based or dexamfetamine-based options, where appropriate)
• Other non-stimulant options may be considered depending on availability and suitability

Your healthcare professional can explain which alternatives may be better suited to your specific needs, medical history, and lifestyle.

Market and legal context in the United Kingdom

In the UK, ADHD medicines are supplied under regulatory frameworks designed to promote safe prescribing and dispensing. Atomoxetine is a medicine with controlled prescribing practices and safety monitoring expectations.

What this means for patients:

• Clinicians should confirm ADHD diagnosis and consider treatment suitability.
• Ongoing reviews help ensure benefits continue and risks remain manageable.
• Pharmacists may provide counselling on safe use, interactions, and side effects.

Medication access is usually through UK primary care pathways and specialist services where appropriate. Local clinical guidelines and national recommendations influence best practice for initiation, titration, and review of ADHD medicines.

Recent guidance and monitoring themes

Across recent UK practice, common themes include:

• Ongoing monitoring: Regular assessment of symptom improvement and side effects.
• Cardiovascular checks: Screening for relevant history and monitoring blood pressure/heart rate.
• Growth and appetite surveillance: Particularly in children and adolescents.
• Attention to mental health: Mood, anxiety, and sleep should be reviewed.
• Individualised prescribing: Choosing treatment based on comorbidities, tolerability, and patient preference.

If you have questions about how your care team is applying current guidance to your situation, your pharmacist or GP can help explain the monitoring plan.

Delivery and availability (UK)

Strattera is generally available through UK pharmacies that stock ADHD medicines, and it may be subject to normal supply schedules. Delivery options depend on the pharmacy and local availability.

Typical availability considerations:

• Stock levels can vary by strength and formulation.
• Some pharmacies may require time to source specific strengths.
• Delivery timeframes depend on the courier and the service level chosen at checkout.

If you need Strattera urgently or have had difficulty obtaining your usual strength, contact your pharmacy to check stock and alternatives (such as switching strengths only if clinically appropriate).

FAQ about Strattera (Atomoxetine)

1) Is Strattera the same as stimulant ADHD medication?

No. Strattera (atomoxetine) is a non-stimulant ADHD medicine. It does not work instantly for most people and is usually taken daily with gradual benefit over weeks.

2) How long does Strattera take to work?

Some improvements may appear within 1–4 weeks, but full benefit can take several weeks. The dose may be adjusted gradually to find the best balance of benefit and side effects.

3) Can I drink alcohol while taking Strattera?

Moderation is advisable. Alcohol may worsen dizziness, tiredness, or mood changes. If you notice side effects after alcohol, avoid it and ask your pharmacist for advice.

4) What if I feel sleepy or get insomnia?

Sleep side effects can happen. Your prescriber may adjust the dose or timing. Do not change your schedule without advice. If symptoms are severe, contact a healthcare professional.

5) Do I need to avoid certain foods?

There are generally no specific foods you must avoid. Taking with food can help if you get nausea. Try to keep a consistent routine unless told otherwise.

6) What medicines interact with atomoxetine?

Atomoxetine can interact with medicines that affect liver enzymes (notably CYP2D6) and with medicines affecting heart rate or blood pressure. Tell your pharmacist about all medicines and supplements you take.

7) Are there effects on heart rate or blood pressure?

Atomoxetine may increase heart rate and/or blood pressure in some people. Your clinician may monitor these measurements, particularly during dose changes or if you have relevant medical history.

8) Is Strattera safe for children and teenagers?

Strattera is used for ADHD in children and adolescents where appropriate. Careful dosing, appetite monitoring, and follow-up are important. Always follow the prescribed plan and attend review appointments.

9) What should I do if I miss a dose?

Follow the instructions in the patient information leaflet or the advice from your pharmacist. As a general rule, avoid doubling up without guidance.

10) Can I stop Strattera suddenly?

Do not stop suddenly unless your clinician instructs you to. If you want to stop or switch treatment, discuss a planned approach with your healthcare professional.

Where to get more help

If you have questions about how to take Strattera, possible side effects, or interactions with other medicines, speak to your pharmacist or healthcare provider. They can help you make the treatment plan safer and more comfortable.